Christopher Jaroniec

CAPS Member

Christopher Jaroniec received his B.S. degree in Chemistry from Kent State University in 1997 and his Ph.D. in Physical Chemistry from the Massachusetts Institute of Technology in 2003, where he was a National Science Foundation Graduate Research Fellow with Robert Griffin, and he was a Damon Runyon Cancer Research Foundation Postdoctoral Fellow with Ad Bax at the National Institutes of Health. He joined The Ohio State University as an Assistant Professor in 2006, was promoted to Associate Professor in 2011 and Professor in 2014, and named Evans Scholar in 2013. Professor Jaroniec has received the CAREER award from the National Science Foundation, the Eli Lilly Young Investigator Award in Analytical Chemistry, the Camille Dreyfus Teacher-Scholar Award, and the Founders' Medal from the International Council on Magnetic Resonance in Biological Systems.

Dr. Jaroniec's research is focused on the development of multidimensional magic-angle spinning solid-state NMR techniques, and their application to the detailed analysis of molecular structure, conformational dynamics and intermolecular interactions of otherwise intractable biological macromolecules that are of fundamental importance to human health. We also develop and apply multidimensional solution-state NMR methods and employ computational, biophysical, biochemical and molecular biology approaches for certain aspects of our work. Current research directions include:

• Development of solid-state NMR methods for probing long range structure in proteins via the incorporation of covalently-bound paramagnetic tags
• Design of NMR pulse sequences for site-resolved measurement of structural and dynamic data in proteins with improved precision and accuracy
• Elucidation of the structural basis of protein conformational inheritance in amyloid and prion diseases
• Characterization of chromatin structure and dynamics
• Structural analysis of biologically-inspired synthetic nanomaterials
• Elucidation of the molecular level interactions between small molecule ligands and supramolecular amyloid peptide and protein assemblies

Dr. Jaroniec's work is currently funded by the National Science Foundation, the National Institutes of Health, the Camille & Henry Dreyfus Foundation, Eli Lilly and the Evans Disease Endowment Fund at Ohio State.

Areas of Expertise
  • Biophysical Chemistry, NMR Spectroscopy
  • Protein Structure & Dynamics, Molecular Self-Assembly

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